Uncovering the Resistance Mechanism of Mycobacterium tuberculosis to Rifampicin Due to RNA Polymerase H451D/Y/R Mutations From Computational Perspective

Uncovering the Resistance Mechanism of Mycobacterium tuberculosis to Rifampicin Due to RNA Polymerase H451D/Y/R Mutations From Computational Perspective

Tuberculosis is still one of the top 10 causes of deaths worldwide, especially with the emergence of multidrug-resistant tuberculosis. Rifampicin, as the most effective first-line antituberculosis drug, also develops resistance due to the mutation on Mycobacterium tuberculosis (Mtb) RNA polymerase....

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Bibliographic Details
Main Authors: Qianqian Zhang, Xiaoli An, Hongli Liu, Shuo Wang, Tong Xiao, Huanxiang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Chemistry
Subjects:
tuberculosis
rifampicin
drug resistance
molecular dynamics simulation
molecular mechanics generalized-Born surface area
dynamic network analysis
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00819/full

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https://www.frontiersin.org/article/10.3389/fchem.2019.00819/full

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