MiR-135-5p promotes osteoblast differentiation by targeting HIF1AN in MC3T3-E1 cells

MiR-135-5p promotes osteoblast differentiation by targeting HIF1AN in MC3T3-E1 cells

Abstract Background MicroRNAs (miRNAs or miRs) serve crucial roles in the progression of osteoporosis. This study investigated the role and specific molecular mechanism of miR-135-5p in regulating osteoblast differentiation and calcification. Methods Bone morphogenetic protein 2 (BMP2) was employed...

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Bibliographic Details
Main Authors: Nuo Yin, Longzhang Zhu, Liang Ding, Junjie Yuan, Li Du, Mingmang Pan, Feng Xue, Haijun Xiao
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
miR-135
Osteoblast differentiation
Calcification
Hypoxia-inducible factor 1 α inhibitor
Online Access:http://link.springer.com/article/10.1186/s11658-019-0177-6

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http://link.springer.com/article/10.1186/s11658-019-0177-6

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