Infrequent RAS mutation is not associated with specific histological phenotype in gliomas

Infrequent RAS mutation is not associated with specific histological phenotype in gliomas

Abstract Background Mutations in driver genes such as IDH and BRAF have been identified in gliomas. Meanwhile, dysregulations in the p53, RB1, and MAPK and/or PI3K pathways are involved in the molecular pathogenesis of glioblastoma. RAS family genes activate MAPK through activation of RAF and PI3K t...

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Bibliographic Details
Main Authors: Yasuhide Makino, Yoshiki Arakawa, Ema Yoshioka, Tomoko Shofuda, Sachiko Minamiguchi, Takeshi Kawauchi, Masahiro Tanji, Daisuke Kanematsu, Masahiro Nonaka, Yoshiko Okita, Yoshinori Kodama, Masayuki Mano, Takanori Hirose, Yohei Mineharu, Susumu Miyamoto, Yonehiro Kanemura
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Cancer
Subjects:
RAS mutation
Glioma
Astrocytoma
Oligodendroglioma
Ganglioglioma
Histological phenotype
Online Access:https://doi.org/10.1186/s12885-021-08733-4

Internet

https://doi.org/10.1186/s12885-021-08733-4

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