Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice.

Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice.

BACKGROUND:The endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) is a known modulator of inflammation and ligand to both, pro-inflammatory cannabinoid receptor 1 (CB1) and anti-inflammatory CB2. While the role of both receptors in atherogenesis has been studied extensively, the significance of 2-A...

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Bibliographic Details
Main Authors: Julian Jehle, Benedikt Schöne, Sayeh Bagheri, Elina Avraamidou, Melina Danisch, Imke Frank, Philipp Pfeifer, Laura Bindila, Beat Lutz, Dieter Lütjohann, Andreas Zimmer, Georg Nickenig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5973571?pdf=render

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http://europepmc.org/articles/PMC5973571?pdf=render

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