Effects of Cellular Methylation on Transgene Expression and Site-Specific Integration of Adeno-Associated Virus

Effects of Cellular Methylation on Transgene Expression and Site-Specific Integration of Adeno-Associated Virus

DNA methylation is a major epigenetic event that affects not only cellular gene expression but that also has the potential to influence bacterial and viral DNA in their host-dependent functions. Adeno-associated virus (AAV) genome contains a high degree of CpG sequences capable of methylation in its...

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Bibliographic Details
Main Authors: Diptiman Chanda, Jonathan A. Hensel, Jerome T. Higgs, Rajat Grover, Niroop Kaza, Selvarangan Ponnazhagan
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Genes
Subjects:
adeno-associated virus
5-Azacytidine
gene expression
site-specific integration
Online Access:https://www.mdpi.com/2073-4425/8/9/232

Internet

https://www.mdpi.com/2073-4425/8/9/232

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