Krüppel like factor 10 prevents intervertebral disc degeneration via TGF-β signaling pathway both in vitro and in vivo

Krüppel like factor 10 prevents intervertebral disc degeneration via TGF-β signaling pathway both in vitro and in vivo

Background: Krüppel like factor 10 (KLF10), which is also known as TGF-β Inducible Early Gene-1 (TIEG1), plays a crucial role in regulating cell proliferation, cell apoptosis and inflammatory reaction in human carcinoma cells. Moreover, KLF10 knockout in mice leads to severe defects associated with...

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Bibliographic Details
Main Authors: Tongde Wu, Xinhua Li, Xuebing Jia, Ziqi Zhu, Jiawei Lu, Hang Feng, Beiduo Shen, Kai Guo, Yuzhi Li, Qiang Wang, Zhiqiang Gao, Bin Yu, Zhaoyu Ba, Yufeng Huang, Desheng Wu
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Journal of Orthopaedic Translation
Subjects:
KLF10
Intervertebral disc degeneration
TGF-β pathway
Nucleus pulposus
Therapeutic strategy
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X21000255

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http://www.sciencedirect.com/science/article/pii/S2214031X21000255

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