Increased Incidence of Colon Tumors in AOM-Treated Apc1638N/+ Mice Reveals Higher Frequency of Tumor Associated Neutrophils in Colon Than Small Intestine

Increased Incidence of Colon Tumors in AOM-Treated Apc1638N/+ Mice Reveals Higher Frequency of Tumor Associated Neutrophils in Colon Than Small Intestine

Colorectal cancer (CRC) is one of the most common cancers and a major cause of mortality. Mice with truncating Apc germline mutations have been used as a standard model of CRC, but most of the Apc-mutated lines develop multiple tumors in the proximal small intestine and rarely in the colon precludin...

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Bibliographic Details
Main Authors: Rebecca Metzger, Mahulena Maruskova, Sabrina Krebs, Klaus-Peter Janssen, Anne B. Krug
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
mouse model
adenomatous polyposis coli
azoxymethane
tumor immunology and microenvironment
tumor-associated neutrophils
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01001/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.01001/full

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