Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome

Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome

The cardiac action potential is critical to the production of a synchronized heartbeat. This electrical impulse is governed by the intricate activity of cardiac ion channels, among them the cardiac voltage-gated potassium (Kv) channels KCNQ1 and hERG as well as the voltage-gated sodium (Nav) channel...

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Bibliographic Details
Main Authors: Kathryn R. Brewer, Georg Kuenze, Carlos G. Vanoye, Alfred L. George, Jens Meiler, Charles R. Sanders
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
cardiac action potential
long QT syndrome
KCNQ1
hERG
SCN5A
structural biology
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00550/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00550/full

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