The intra-articular injection of RANKL-binding peptides inhibits cartilage degeneration in a murine model of osteoarthritis

The intra-articular injection of RANKL-binding peptides inhibits cartilage degeneration in a murine model of osteoarthritis

We recently found that the receptor activator of NF-κB ligand (RANKL)-binding peptide, OP3-4 stimulated the differentiation of both chondrocytes and osteoblasts. OP3-4 is also shown to inhibit cartilage degeneration. To clarify whether the peptide can inhibit cartilage degeneration without stimulati...

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Bibliographic Details
Main Authors: Md. Zahirul Haque Bhuyan, Yukihiko Tamura, Eri Sone, Yuki Yoshinari, Chizuko Maeda, Mariko Takahashi, Yasuhiko Tabata, Ramachandran Murali, Yoshihiro Waki, Kazuhiro Aoki
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Journal of Pharmacological Sciences
Subjects:
RANKL-binding peptide
Osteoarthritis
Cartilage repair
Monosodium iodoacetate (MIA)
Mesenchymal stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131730083X

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http://www.sciencedirect.com/science/article/pii/S134786131730083X

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