BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer

BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer

Abstract Background Germline mutations in the BRIP1 gene have been described as conferring a moderate risk for ovarian cancer (OC), while the role of BRIP1 in breast cancer (BC) pathogenesis remains controversial. Methods To assess the role of deleterious BRIP1 germline mutations in BC/OC predisposi...

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Bibliographic Details
Main Authors: Nana Weber-Lassalle, Jan Hauke, Juliane Ramser, Lisa Richters, Eva Groß, Britta Blümcke, Andrea Gehrig, Anne-Karin Kahlert, Clemens R. Müller, Karl Hackmann, Ellen Honisch, Konstantin Weber-Lassalle, Dieter Niederacher, Julika Borde, Holger Thiele, Corinna Ernst, Janine Altmüller, Guido Neidhardt, Peter Nürnberg, Kristina Klaschik, Christopher Schroeder, Konrad Platzer, Alexander E. Volk, Shan Wang-Gohrke, Walter Just, Bernd Auber, Christian Kubisch, Gunnar Schmidt, Judit Horvath, Barbara Wappenschmidt, Christoph Engel, Norbert Arnold, Bernd Dworniczak, Kerstin Rhiem, Alfons Meindl, Rita K. Schmutzler, Eric Hahnen
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Ovarian cancer
BRIP1 gene
Germline mutations
Online Access:http://link.springer.com/article/10.1186/s13058-018-0935-9

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http://link.springer.com/article/10.1186/s13058-018-0935-9

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