Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy

Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy

Chronic Chagasic cardiomyopathy (CCC) is a severe clinical manifestation that develops in 30%–40% of individuals chronically infected with the protozoal parasite Trypanosoma cruzi and is thus an important public health problem. Parasite persistence during chronic infection drives pathologic changes...

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Bibliographic Details
Main Authors: Kristyn A. Hoffman, Maria Jose Villar, Cristina Poveda, Maria Elena Bottazzi, Peter J. Hotez, David J. Tweardy, Kathryn M. Jones
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
STAT3
fibrosis
chronic Chagasic cardiomyopathy
inflammation
Trypanosoma cruzi
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.708325/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.708325/full

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