2-Methoxyestradiol Exhibits a Biphasic Effect on VEGF-A in Tumor Cells and Upregulation Is Mediated Through ER-α: A Possible Signaling Pathway Associated with the Impact of 2-ME2 on Proliferative Cells

2-Methoxyestradiol Exhibits a Biphasic Effect on VEGF-A in Tumor Cells and Upregulation Is Mediated Through ER-α: A Possible Signaling Pathway Associated with the Impact of 2-ME2 on Proliferative Cells

2-Methoxyestradiol (2-ME2) was reported to elicit both stimulation and inhibition of tumor angiogenesis and growth depending on the dosage used. However, the mechanism(s) of the biphasic action of 2-ME2 has been elusive. Here we describe a regulatory role of vascular endothelial growth factor-A (VE...

Full description

Bibliographic Details
Main Authors: Samarendra N. Banerjee, Krishanu Sengupta, Snigdha Banerjee, Neela K. Saxena, Sushanta K. Banerjee
Format: Article
Language:English
Published: Elsevier 2003-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
2-methoxyestadiol
VEGF
ER-alpha
human mammary epithelial cells
transfection
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558603800441

Internet

http://www.sciencedirect.com/science/article/pii/S1476558603800441

Similar Items