Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model

Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model

Abstract Background Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disorder caused by maternal antibodies against paternal human platelet antigens (HPAs) on fetal platelets. Antibodies against HPA-1a are accountable for the majority of FNAIT cases. We have previously shown that...

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Bibliographic Details
Main Authors: Mariana Eksteen, Gøril Heide, Heidi Tiller, Yan Zhou, Nora Hersoug Nedberg, Inigo Martinez-Zubiaurre, Anne Husebekk, Bjørn R. Skogen, Tor B. Stuge, Mette Kjær
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Reproductive Biology and Endocrinology
Subjects:
Alloimmunization
HPA-1a
Anti-HPA-1a antibodies
Trophoblast cells
Placental development
αVβ3
Online Access:http://link.springer.com/article/10.1186/s12958-017-0245-6

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http://link.springer.com/article/10.1186/s12958-017-0245-6

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