Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid Neoplasia

Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid Neoplasia

Chromosomal instability (CIN) is a characteristic feature of cancer. In this review, we concentrate on mechanisms leading to CIN in myeloid neoplasia, i.e., myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The pathogenesis of myeloid neoplasia is complex and involves genetic and epige...

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Bibliographic Details
Main Authors: Brigitte Schlegelberger, Beate Vajen, Kathrin Thomay
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Cancers
Subjects:
chromosomal instability
myeloid leukemia
MDS
AML
telomeres
epigenetics
genetic instability
Online Access:http://www.mdpi.com/2072-6694/5/3/857

Internet

http://www.mdpi.com/2072-6694/5/3/857

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