The crystal structures of apo and cAMP-bound GlxR from Corynebacterium glutamicum reveal structural and dynamic changes upon cAMP binding in CRP/FNR family transcription factors.

The crystal structures of apo and cAMP-bound GlxR from Corynebacterium glutamicum reveal structural and dynamic changes upon cAMP binding in CRP/FNR family transcription factors.

The cyclic AMP-dependent transcriptional regulator GlxR from Corynebacterium glutamicum is a member of the super-family of CRP/FNR (cyclic AMP receptor protein/fumarate and nitrate reduction regulator) transcriptional regulators that play central roles in bacterial metabolic regulatory networks. In...

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Bibliographic Details
Main Authors: Philip D Townsend, Britta Jungwirth, Florence Pojer, Michael Bußmann, Victoria A Money, Stewart T Cole, Alfred Pühler, Andreas Tauch, Michael Bott, Martin J Cann, Ehmke Pohl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0113265

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https://doi.org/10.1371/journal.pone.0113265

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