Pan-cancer analysis reveals technical artifacts in TCGA germline variant calls

Pan-cancer analysis reveals technical artifacts in TCGA germline variant calls

Abstract Background Cancer research to date has largely focused on somatically acquired genetic aberrations. In contrast, the degree to which germline, or inherited, variation contributes to tumorigenesis remains unclear, possibly due to a lack of accessible germline variant data. Here we called ger...

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Bibliographic Details
Main Authors: Alexandra R. Buckley, Kristopher A. Standish, Kunal Bhutani, Trey Ideker, Roger S. Lasken, Hannah Carter, Olivier Harismendy, Nicholas J. Schork
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Genomics
Subjects:
Cancer genomics
TCGA
Cancer germline
Whole exome sequencing
Variant calling
GATK
Online Access:http://link.springer.com/article/10.1186/s12864-017-3770-y

Internet

http://link.springer.com/article/10.1186/s12864-017-3770-y

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