A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.

A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.

Insulin signaling has a profound effect on longevity and the oxidative stress resistance of animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf transcription factors and increased animal fitness. By studying the biological functions of the endogenous RNA i...

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Bibliographic Details
Main Authors: Andres R Mansisidor, Germano Cecere, Sebastian Hoersch, Morten B Jensen, Trupti Kawli, Lisa M Kennedy, Violeta Chavez, Man-Wah Tan, Jason D Lieb, Alla Grishok
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3183084?pdf=render

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http://europepmc.org/articles/PMC3183084?pdf=render

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