TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload

TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload

Background & Aims: As the composition of the bile acid (BA) pool has a major impact on liver pathophysiology, we studied its regulation by the BA receptor Takeda G protein coupled receptor (TGR5), which promotes hepatoprotection against BA overload. Methods: Wild-type, total and hepatocyte-s...

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Bibliographic Details
Main Authors: Valeska Bidault-Jourdainne, Grégory Merlen, Mathilde Glénisson, Isabelle Doignon, Isabelle Garcin, Noémie Péan, Raphael Boisgard, José Ursic-Bedoya, Matteo Serino, Christoph Ullmer, Lydie Humbert, Ahmed Abdelrafee, Nicolas Golse, Eric Vibert, Jean-Charles Duclos-Vallée, Dominique Rainteau, Thierry Tordjmann
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:JHEP Reports
Subjects:
Gallbladder
Bile acids
GPBAR1
TGR5
Hepatoprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555920301488

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http://www.sciencedirect.com/science/article/pii/S2589555920301488

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