Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA

Summary: Human induced pluripotent stem cells (hiPSCs) can serve as a versatile and scalable source of neutrophils for biomedical research and transfusion therapies. Here we describe a rapid efficient serum- and xenogen-free protocol for neutrophil generation, which is based on direct hematoendothel...

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Bibliographic Details
Main Authors: Vera S. Brok-Volchanskaya, David A. Bennin, Kran Suknuntha, Lucas C. Klemm, Anna Huttenlocher, Igor Slukvin
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119303686