Towards Mimicking the Fetal Liver Niche: The Influence of Elasticity and Oxygen Tension on Hematopoietic Stem/Progenitor Cells Cultured in 3D Fibrin Hydrogels

Towards Mimicking the Fetal Liver Niche: The Influence of Elasticity and Oxygen Tension on Hematopoietic Stem/Progenitor Cells Cultured in 3D Fibrin Hydrogels

Hematopoietic stem/progenitor cells (HSPCs) are responsible for the generation of blood cells throughout life. It is believed that, in addition to soluble cytokines and niche cells, biophysical cues like elasticity and oxygen tension are responsible for the orchestration of stem cell fate. Although...

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Bibliographic Details
Main Authors: Christian Garcia-Abrego, Samantha Zaunz, Burak Toprakhisar, Ramesh Subramani, Olivier Deschaume, Stijn Jooken, Manmohan Bajaj, Herman Ramon, Catherine Verfaillie, Carmen Bartic, Jennifer Patterson
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
fibrin hydrogel
elastic modulus
hematopoietic stem cells
fetal liver niche
3D cell encapsulation
oxygen tension
Online Access:https://www.mdpi.com/1422-0067/21/17/6367

Internet

https://www.mdpi.com/1422-0067/21/17/6367

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