High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin

α1-Antitrypsin (AAT) is a 52 kDa serum glycoprotein, the misfolding and polymerisation of which is associated with COPD and liver disease. Here the authors demonstrate the use of high-resolution multidimensional solution-state NMR spectroscopy to characterise the structure and dynamics in solution o...

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Bibliographic Details
Main Authors: Alistair M. Jagger, Christopher A. Waudby, James A. Irving, John Christodoulou, David A. Lomas
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20147-7