Orphan CpG islands identify numerous conserved promoters in the mammalian genome.

Orphan CpG islands identify numerous conserved promoters in the mammalian genome.

CpG islands (CGIs) are vertebrate genomic landmarks that encompass the promoters of most genes and often lack DNA methylation. Querying their apparent importance, the number of CGIs is reported to vary widely in different species and many do not co-localise with annotated promoters. We set out to qu...

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Bibliographic Details
Main Authors: Robert S Illingworth, Ulrike Gruenewald-Schneider, Shaun Webb, Alastair R W Kerr, Keith D James, Daniel J Turner, Colin Smith, David J Harrison, Robert Andrews, Adrian P Bird
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2944787?pdf=render

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http://europepmc.org/articles/PMC2944787?pdf=render

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