ATP citrate lyase inhibitor Bempedoic Acid alleviate long term HFD induced NASH through improvement in glycemic control, reduction of hepatic triglycerides & total cholesterol, modulation of inflammatory & fibrotic genes and improvement in NAS score

ATP citrate lyase inhibitor Bempedoic Acid alleviate long term HFD induced NASH through improvement in glycemic control, reduction of hepatic triglycerides & total cholesterol, modulation of inflammatory & fibrotic genes and improvement in NAS score

Non-alcoholic fatty liver disease (NAFLD) and Non-alcoholic steatohepatitis (NASH) are chronic liver disorders, the prevalence of which is increasing worldwide. Long term High Fat Diet (HFD) induced NASH animal models closely mimic the characteristics of human NASH and hence used by investigators as...

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Bibliographic Details
Main Authors: K.V. Sanjay, Santosh Vishwakarma, Bharat Ravindra Zope, Vishal Subhash Mane, Sunil Mohire, Saravanakumar Dhakshinamoorthy
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Current Research in Pharmacology and Drug Discovery
Subjects:
Nonalcoholic fatty liver disease
Nonalcoholic steatohepatitis
ATP citrate Lyase
Bempedoic acid
Inflammation
Fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590257121000389

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http://www.sciencedirect.com/science/article/pii/S2590257121000389

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