Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions

Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions

Intrinsically disordered linkers provide multi-domain proteins with degrees of conformational freedom that are often essential for function. These highly dynamic assemblies represent a significant fraction of all proteomes, and deciphering the physical basis of their interactions represents a consid...

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Bibliographic Details
Main Authors: Elise Delaforge, Sigrid Milles, Jie-rong Huang, Denis Bouvier, Malene Ringkjøbing Jensen, Darren Hart, Michael Sattler, Martin Blackledge
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
Nuclear Magnetic Resonance
protein
Conformational selection
Small-angle scattering
Chemical exchange saturation transfer (CEST)
conformational dynamics
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00054/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00054/full

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