Mutational Landscape of the BAP1 Locus Reveals an Intrinsic Control to Regulate the miRNA Network and the Binding of Protein Complexes in Uveal Melanoma

Mutational Landscape of the BAP1 Locus Reveals an Intrinsic Control to Regulate the miRNA Network and the Binding of Protein Complexes in Uveal Melanoma

The <i>BAP1</i> (BRCA1-associated protein 1) gene is associated with a variety of human cancers. With its gene product being a nuclear ubiquitin carboxy-terminal hydrolase with deubiquitinase activity, <i>BAP1</i> acts as a tumor suppressor gene with potential pleiotropic eff...

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Bibliographic Details
Main Authors: Amit Sharma, Arijit Biswas, Hongde Liu, Sagnik Sen, Anoosha Paruchuri, Panagiotis Katsonis, Olivier Lichtarge, Tikam Chand Dakal, Ujjwal Maulik, M. Michael Gromiha, Sanghamitra Bandyopadhyay, Michael Ludwig, Frank G. Holz, Karin U. Loeffler, Martina C. Herwig-Carl
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
bap1
uveal melanoma
uch domain
mirnas
tcga
hcf-1
foxk2
asxl1
bard1
brca1
evolutionary action score
Online Access:https://www.mdpi.com/2072-6694/11/10/1600

Internet

https://www.mdpi.com/2072-6694/11/10/1600

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