Cellular cholesterol efflux in heterozygotes for Tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size

Cellular cholesterol efflux in heterozygotes for Tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size

Tangier disease (TD), caused by mutations in the ATP-binding cassette 1 (ABC-1) gene, is a rare genetic disorder characterized by severe deficiency of high density lipoproteins (HDL) in the plasma, hypercatabolism of HDL, and defective apolipoprotein (apo)-mediated cellular cholesterol efflux. In th...

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Bibliographic Details
Main Authors: Margaret E. Brousseau, Gretchen P. Eberhart, Josée Dupuis, Bela F. Asztalos, Allison L. Goldkamp, Ernst J. Schaefer, Mason W. Freeman
Format: Article
Language:English
Published: Elsevier 2000-07-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein
ATP-binding cassette 1
cholesterol
efflux
lipoproteins
Tangier disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520320198

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520320198

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