Newfound effect of N-acetylaspartate in preventing and reversing aggregation of amyloid-beta in vitro

Newfound effect of N-acetylaspartate in preventing and reversing aggregation of amyloid-beta in vitro

Although N-acetylaspartate (NAA) has long been recognized as the most abundant amino acid in neurons by far, its primary role has remained a mystery. Based on its unique tertiary structure, we explored the potential of NAA to modulate aggregation of amyloid-beta (Aβ) peptide 1-42 via multiple corrob...

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Bibliographic Details
Main Authors: Jean-Pierre Dollé, Jeffrey M. Rodgers, Kevin D. Browne, Thomas Troxler, Feng Gai, Douglas H. Smith
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Neurobiology of Disease
Subjects:
N-Acetylaspartate
Amyloid beta
Aggregation inhibitor
Thioflavin-T
Fluorescence correlation spectroscopy
Dynamic light scattering
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611830161X

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http://www.sciencedirect.com/science/article/pii/S096999611830161X

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