Physical Activity and Inhibition of ACE Additively Modulate ACE/ACE-2 Balance in Heart Failure in Mice

Physical Activity and Inhibition of ACE Additively Modulate ACE/ACE-2 Balance in Heart Failure in Mice

Angiotensin-converting enzyme inhibition (ACE-I) and physical activity favorably modulate the ACE/ACE-2 balance. However, it is not clear whether physical activity and ACE-I could synergistically modulate ACE/ACE-2 balance in the course of heart failure (HF). Here, we studied the effects of combined...

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Bibliographic Details
Main Authors: Urszula Tyrankiewicz, Mariola Olkowicz, Piotr Berkowicz, Magdalena Jablonska, Ryszard T. Smolenski, Jerzy A. Zoladz, Stefan Chlopicki
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
heart failure
angiotensins
angiotensin-converting enzyme inhibition
spontaneous physical activity
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.682432/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.682432/full

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