Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting

Fasting is known for its beneficial effects on obesity and diabetes-related health complications. Here Zhang et al. show that fasting induces expression of arginase-2 (Arg2) in the liver, and that hepatic Arg2, by suppressing the expression of the regulator of G-protein signalling 16, recapitulates...

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Bibliographic Details
Main Authors: Yiming Zhang, Cassandra B. Higgins, Hannah M. Fortune, Phillip Chen, Alicyn I. Stothard, Allyson L. Mayer, Benjamin M. Swarts, Brian J. DeBosch
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09642-8