Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting

Fasting is known for its beneficial effects on obesity and diabetes-related health complications. Here Zhang et al. show that fasting induces expression of arginase-2 (Arg2) in the liver, and that hepatic Arg2, by suppressing the expression of the regulator of G-protein signalling 16, recapitulates...

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Main Authors:	Yiming Zhang, Cassandra B. Higgins, Hannah M. Fortune, Phillip Chen, Alicyn I. Stothard, Allyson L. Mayer, Benjamin M. Swarts, Brian J. DeBosch
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09642-8

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spelling	doaj-954749bafaf0425d8c21a4c09fdcf9472021-05-11T12:16:35ZengNature Publishing GroupNature Communications2041-17232019-04-0110111610.1038/s41467-019-09642-8Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fastingYiming Zhang0Cassandra B. Higgins1Hannah M. Fortune2Phillip Chen3Alicyn I. Stothard4Allyson L. Mayer5Benjamin M. Swarts6Brian J. DeBosch7Department of Pediatrics, Washington University School of MedicineDepartment of Pediatrics, Washington University School of MedicineDepartment of Pediatrics, Washington University School of MedicineDepartment of Pediatrics, Washington University School of MedicineDepartment of Chemistry & Biochemistry, Central Michigan UniversityDepartment of Pediatrics, Washington University School of MedicineDepartment of Chemistry & Biochemistry, Central Michigan UniversityDepartment of Pediatrics, Washington University School of MedicineFasting is known for its beneficial effects on obesity and diabetes-related health complications. Here Zhang et al. show that fasting induces expression of arginase-2 (Arg2) in the liver, and that hepatic Arg2, by suppressing the expression of the regulator of G-protein signalling 16, recapitulates the positive effects of fasting in obesity and diabetes.https://doi.org/10.1038/s41467-019-09642-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yiming Zhang Cassandra B. Higgins Hannah M. Fortune Phillip Chen Alicyn I. Stothard Allyson L. Mayer Benjamin M. Swarts Brian J. DeBosch
spellingShingle	Yiming Zhang Cassandra B. Higgins Hannah M. Fortune Phillip Chen Alicyn I. Stothard Allyson L. Mayer Benjamin M. Swarts Brian J. DeBosch Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting Nature Communications
author_facet	Yiming Zhang Cassandra B. Higgins Hannah M. Fortune Phillip Chen Alicyn I. Stothard Allyson L. Mayer Benjamin M. Swarts Brian J. DeBosch
author_sort	Yiming Zhang
title	Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
title_short	Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
title_full	Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
title_fullStr	Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
title_full_unstemmed	Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
title_sort	hepatic arginase 2 (arg2) is sufficient to convey the therapeutic metabolic effects of fasting
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-04-01
description	Fasting is known for its beneficial effects on obesity and diabetes-related health complications. Here Zhang et al. show that fasting induces expression of arginase-2 (Arg2) in the liver, and that hepatic Arg2, by suppressing the expression of the regulator of G-protein signalling 16, recapitulates the positive effects of fasting in obesity and diabetes.
url	https://doi.org/10.1038/s41467-019-09642-8
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Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting

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