Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
Fasting is known for its beneficial effects on obesity and diabetes-related health complications. Here Zhang et al. show that fasting induces expression of arginase-2 (Arg2) in the liver, and that hepatic Arg2, by suppressing the expression of the regulator of G-protein signalling 16, recapitulates...
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2019-04-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-09642-8 |
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doaj-954749bafaf0425d8c21a4c09fdcf9472021-05-11T12:16:35ZengNature Publishing GroupNature Communications2041-17232019-04-0110111610.1038/s41467-019-09642-8Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fastingYiming Zhang0Cassandra B. Higgins1Hannah M. Fortune2Phillip Chen3Alicyn I. Stothard4Allyson L. Mayer5Benjamin M. Swarts6Brian J. DeBosch7Department of Pediatrics, Washington University School of MedicineDepartment of Pediatrics, Washington University School of MedicineDepartment of Pediatrics, Washington University School of MedicineDepartment of Pediatrics, Washington University School of MedicineDepartment of Chemistry & Biochemistry, Central Michigan UniversityDepartment of Pediatrics, Washington University School of MedicineDepartment of Chemistry & Biochemistry, Central Michigan UniversityDepartment of Pediatrics, Washington University School of MedicineFasting is known for its beneficial effects on obesity and diabetes-related health complications. Here Zhang et al. show that fasting induces expression of arginase-2 (Arg2) in the liver, and that hepatic Arg2, by suppressing the expression of the regulator of G-protein signalling 16, recapitulates the positive effects of fasting in obesity and diabetes.https://doi.org/10.1038/s41467-019-09642-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yiming Zhang Cassandra B. Higgins Hannah M. Fortune Phillip Chen Alicyn I. Stothard Allyson L. Mayer Benjamin M. Swarts Brian J. DeBosch |
spellingShingle |
Yiming Zhang Cassandra B. Higgins Hannah M. Fortune Phillip Chen Alicyn I. Stothard Allyson L. Mayer Benjamin M. Swarts Brian J. DeBosch Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting Nature Communications |
author_facet |
Yiming Zhang Cassandra B. Higgins Hannah M. Fortune Phillip Chen Alicyn I. Stothard Allyson L. Mayer Benjamin M. Swarts Brian J. DeBosch |
author_sort |
Yiming Zhang |
title |
Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting |
title_short |
Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting |
title_full |
Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting |
title_fullStr |
Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting |
title_full_unstemmed |
Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting |
title_sort |
hepatic arginase 2 (arg2) is sufficient to convey the therapeutic metabolic effects of fasting |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-04-01 |
description |
Fasting is known for its beneficial effects on obesity and diabetes-related health complications. Here Zhang et al. show that fasting induces expression of arginase-2 (Arg2) in the liver, and that hepatic Arg2, by suppressing the expression of the regulator of G-protein signalling 16, recapitulates the positive effects of fasting in obesity and diabetes. |
url |
https://doi.org/10.1038/s41467-019-09642-8 |
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