Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid

Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid

As p300-mediated RelA/p65 hyperacetylation by signal transducers and activators of transcription 3 (STAT3) is critical for NF-κB activation, in the current study, the apoptotic mechanism of lambertianic acid (LA) was explored in relation to STAT3 phosphorylation and RelA/p65 acetylation in...

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Bibliographic Details
Main Authors: Deok Yong Sim, Hyo-Jung Lee, Ji Hoon Jung, Eunji Im, Jisung Hwang, Dong Sub Kim, Sung-Hoon Kim
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
Lambertianic acid
STAT3
NF-κB
p300
Ac-RelA/p65
Online Access:https://www.mdpi.com/1422-0067/20/12/2993

Internet

https://www.mdpi.com/1422-0067/20/12/2993

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