Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures

We have investigated the properties of the dopaminergic neurotoxins 6-hydroxydopamine, 1-methyl-4-phenylpyridinium and rotenone using an organotypic culture that included slices of substantia nigra, striatum and cortex maintained for about 20 days in vitro. At this age, the organotypic culture conta...

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Bibliographic Details
Main Authors: Geraldine J. Kress, Ian J. Reynolds
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001270