Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration.

Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration.

Expression of the Endothelin-2 (Edn2) mRNA is greatly increased in the photoreceptors (PRs) of mouse models of inherited PR degeneration (IPD). To examine the role of Edn2 in mutant PR survival, we generated Edn2(-/-) mice carrying homozygous Pde6b(rd1) alleles or the Tg(RHO P347S) transgene. In the...

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Bibliographic Details
Main Authors: Alexa N Bramall, Michael J Szego, Laura R Pacione, Inik Chang, Eduardo Diez, Pedro D'Orleans-Juste, Duncan J Stewart, William W Hauswirth, Masashi Yanagisawa, Roderick R McInnes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3585171?pdf=render

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http://europepmc.org/articles/PMC3585171?pdf=render

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