Identification of Novel Protein Kinase Receptor Type 2 Inhibitors Using Pharmacophore and Structure-Based Virtual Screening

Identification of Novel Protein Kinase Receptor Type 2 Inhibitors Using Pharmacophore and Structure-Based Virtual Screening

The Protein Kinase Receptor type 2 (RIPK2) plays an important role in the pathogenesis of inflammatory diseases; it signals downstream of the NOD1 and NOD2 intracellular sensors and promotes a productive inflammatory response. However, excessive NOD2 signaling has been associated with various diseas...

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Bibliographic Details
Main Authors: Josiane V. Cruz, Moysés F. A. Neto, Luciane B. Silva, Ryan da S. Ramos, Josivan da S. Costa, Davi S. B. Brasil, Cleison C. Lobato, Glauber V. da Costa, José Adolfo H. M. Bittencourt, Carlos H. T. P. da Silva, Franco H. A. Leite, Cleydson B. R. Santos
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
RIPK2
ponatinib
WEHI-345
virtual screening
rheumatoid arthritis
anti-inflammatory
Online Access:http://www.mdpi.com/1420-3049/23/2/453

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http://www.mdpi.com/1420-3049/23/2/453

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