Structural transitions during the scaffolding-driven assembly of a viral capsid

Structural transitions during the scaffolding-driven assembly of a viral capsid

Viral assembly is a complex process that in tailed bacteriophages involves scaffolding proteins which coordinate assembly of the phage procapsid and are subsequently released during maturation. Here the authors reveal the conformational changes that accompany virion maturation, documenting how the d...

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Main Authors: Athanasios Ignatiou, Sandrine Brasilès, Mehdi El Sadek Fadel, Jörg Bürger, Thorsten Mielke, Maya Topf, Paulo Tavares, Elena V. Orlova
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12790-6
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spelling doaj-9550faea551f487fbc11250461307f8f2021-05-11T12:16:21ZengNature Publishing GroupNature Communications2041-17232019-10-0110111110.1038/s41467-019-12790-6Structural transitions during the scaffolding-driven assembly of a viral capsidAthanasios Ignatiou0Sandrine Brasilès1Mehdi El Sadek Fadel2Jörg Bürger3Thorsten Mielke4Maya Topf5Paulo Tavares6Elena V. Orlova7Institute of Structural and Molecular Biology, Birkbeck CollegeDepartment of Virology, Institut de Biologie Intégrative de la Cellule (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-SaclayDepartment of Virology, Institut de Biologie Intégrative de la Cellule (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-SaclayMax-Planck-Institut für Molekulare Genetik, Microscopy and Cryo-Electron Microscopy GroupMax-Planck-Institut für Molekulare Genetik, Microscopy and Cryo-Electron Microscopy GroupInstitute of Structural and Molecular Biology, Birkbeck CollegeDepartment of Virology, Institut de Biologie Intégrative de la Cellule (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-SaclayInstitute of Structural and Molecular Biology, Birkbeck CollegeViral assembly is a complex process that in tailed bacteriophages involves scaffolding proteins which coordinate assembly of the phage procapsid and are subsequently released during maturation. Here the authors reveal the conformational changes that accompany virion maturation, documenting how the dissociation of scaffold proteins and DNA packaging processes intersect.https://doi.org/10.1038/s41467-019-12790-6
collection DOAJ
language English
format Article
sources DOAJ
author Athanasios Ignatiou
Sandrine Brasilès
Mehdi El Sadek Fadel
Jörg Bürger
Thorsten Mielke
Maya Topf
Paulo Tavares
Elena V. Orlova
spellingShingle Athanasios Ignatiou
Sandrine Brasilès
Mehdi El Sadek Fadel
Jörg Bürger
Thorsten Mielke
Maya Topf
Paulo Tavares
Elena V. Orlova
Structural transitions during the scaffolding-driven assembly of a viral capsid
Nature Communications
author_facet Athanasios Ignatiou
Sandrine Brasilès
Mehdi El Sadek Fadel
Jörg Bürger
Thorsten Mielke
Maya Topf
Paulo Tavares
Elena V. Orlova
author_sort Athanasios Ignatiou
title Structural transitions during the scaffolding-driven assembly of a viral capsid
title_short Structural transitions during the scaffolding-driven assembly of a viral capsid
title_full Structural transitions during the scaffolding-driven assembly of a viral capsid
title_fullStr Structural transitions during the scaffolding-driven assembly of a viral capsid
title_full_unstemmed Structural transitions during the scaffolding-driven assembly of a viral capsid
title_sort structural transitions during the scaffolding-driven assembly of a viral capsid
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-10-01
description Viral assembly is a complex process that in tailed bacteriophages involves scaffolding proteins which coordinate assembly of the phage procapsid and are subsequently released during maturation. Here the authors reveal the conformational changes that accompany virion maturation, documenting how the dissociation of scaffold proteins and DNA packaging processes intersect.
url https://doi.org/10.1038/s41467-019-12790-6
work_keys_str_mv AT athanasiosignatiou structuraltransitionsduringthescaffoldingdrivenassemblyofaviralcapsid
AT sandrinebrasiles structuraltransitionsduringthescaffoldingdrivenassemblyofaviralcapsid
AT mehdielsadekfadel structuraltransitionsduringthescaffoldingdrivenassemblyofaviralcapsid
AT jorgburger structuraltransitionsduringthescaffoldingdrivenassemblyofaviralcapsid
AT thorstenmielke structuraltransitionsduringthescaffoldingdrivenassemblyofaviralcapsid
AT mayatopf structuraltransitionsduringthescaffoldingdrivenassemblyofaviralcapsid
AT paulotavares structuraltransitionsduringthescaffoldingdrivenassemblyofaviralcapsid
AT elenavorlova structuraltransitionsduringthescaffoldingdrivenassemblyofaviralcapsid
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