Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model

Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model

Abstract Background Previous studies report that lipopolysaccharide (LPS)-preconditioned mesenchymal stem cells have enhanced trophic support and improved regenerative and repair properties. Extracellular vesicles secreted by synovial mesenchymal stem cells (EVs) can reduce cartilage damage caused b...

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Bibliographic Details
Main Authors: Ao Duan, Kai Shen, Beichen Li, Cong Li, Hao Zhou, Renyi Kong, Yuqi Shao, Jian Qin, Tangbo Yuan, Juan Ji, Wei Guo, Xipeng Wang, Tengfei Xue, Lei Li, Xinxin Huang, Yuqin Sun, Zhenyu Cai, Wei Liu, Feng Liu
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Stem Cell Research & Therapy
Subjects:
Osteoarthritis
Extracellular vesicles
LPS-precondition
Let-7b
ADAMTS5
Online Access:https://doi.org/10.1186/s13287-021-02507-2

Internet

https://doi.org/10.1186/s13287-021-02507-2

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