E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis[S]

E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis[S]

Upon food intake, insulin stimulates de novo lipogenesis (DNL) in hepatocytes via the AKT-mTORC1-sterol regulatory element-binding protein (SREBP)-1c pathway. How insulin maintains the maximal SREBP-1c activities during the entire feeding state remains elusive. We previously reported that insulin in...

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Bibliographic Details
Main Authors: Xin Tong, Pei Li, Deqiang Zhang, Kyle VanDommelen, Neil Gupta, Liangyou Rui, M. Bishr Omary, Lei Yin
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Journal of Lipid Research
Subjects:
insulin signaling
de novo lipogenesis
sterol regulatory element-binding protein 1c
E4-binding protein 4
fatty acid synthesis
lipids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351580

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http://www.sciencedirect.com/science/article/pii/S0022227520351580

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