Astrocytes Are More Resistant Than Neurons to the Cytotoxic Effects of Increased [Zn2+]i

Increased intracellular free Zn2+ ([Zn2+]i) is toxic to neurons. Glia are more resistant to Zn2+-mediated toxicity; however, it is not known if this is because glia are less permeable to Zn2+ or if glia possess intrinsic mechanisms that serve to buffer or extrude excess [Zn2+]i. We used the Zn2+-sel...

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Bibliographic Details
Main Authors: K.E. Dineley, J.M. Scanlon, G.J. Kress, A.K. Stout, I.J. Reynolds
Format: Article
Language:English
Published: Elsevier 2000-08-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100903036