Succinate and the shortcut to the cure of metformin-induced lactic acidosis

Succinate and the shortcut to the cure of metformin-induced lactic acidosis

Abstract Inhibition of the respiratory chain complex I plays a key role in the pathogenesis of metformin-induced lactic acidosis. In a work recently published in this journal, a novel cell-permeable succinate prodrug (NV118) increased in vitro mitochondrial oxygen consumption coupled with energy pro...

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Bibliographic Details
Main Author: Alessandro Protti
Format: Article
Language:English
Published: SpringerOpen 2018-09-01
Series:Intensive Care Medicine Experimental
Subjects:
Metformin
Lactic acidosis
Succinate
Mitochondria
Hypoxia
Intoxication
Online Access:http://link.springer.com/article/10.1186/s40635-018-0202-5

Internet

http://link.springer.com/article/10.1186/s40635-018-0202-5

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