Biphasic Dissolution as an Exploratory Method During Early Drug Product Development

Biphasic Dissolution as an Exploratory Method During Early Drug Product Development

Dissolution testing is a major tool used to assess a drug product’s performance and as a quality control test for solid oral dosage forms. However, compendial equipment and methods may lack discriminatory power and the ability to simulate aspects of in vivo dissolution. Using low buffer capacity med...

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Bibliographic Details
Main Authors: Daniela Amaral Silva, Jozef Al-Gousous, Neal M. Davies, Nadia Bou Chacra, Gregory K. Webster, Elke Lipka, Gordon L. Amidon, Raimar Löbenberg
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
biphasic dissolution
drug product development
buffer capacity
physiologically relevant
ibuprofen
Online Access:https://www.mdpi.com/1999-4923/12/5/420

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https://www.mdpi.com/1999-4923/12/5/420

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