Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins

Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins

The KDM4 histone demethylase subfamily is constituted of yeast JmjC domain-containing proteins, such as Gis1, and human Gis1 orthologues, such as KDM4A/B/C. KDM4 proteins have important functions in regulating chromatin structure and gene expression in response to metabolic and nutritional stimuli....

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Bibliographic Details
Main Authors: Purna Chaitanya Konduri, Tianyuan Wang, Narges Salamat, Li Zhang
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
gis1
kdm4
heme
histone demethylase
protein interaction
jmjc domain
Online Access:https://www.mdpi.com/2073-4409/9/3/773

Internet

https://www.mdpi.com/2073-4409/9/3/773

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