Helix-A peptide prevents gp120-mediated neuronal loss

Helix-A peptide prevents gp120-mediated neuronal loss

Abstract Aim The human-immunodeficiency virus (HIV) envelope protein gp120 promotes synaptic damage similar to that observed in people living with HIV who have neurocognitive disorders. The neurotoxic effect of gp120 appears to occur through the α-helix motif that binds to neuronal microtubules (MTs...

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Bibliographic Details
Main Authors: Valeria Avdoshina, Francesca Taraballi, Ennio Tasciotti, Aykut Üren, Italo Mocchetti
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Molecular Brain
Subjects:
Dendritic simplification
HAND
HIV
Mesoporous nanoparticles
Microtubules
Neuronal survival
Online Access:http://link.springer.com/article/10.1186/s13041-019-0482-z

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http://link.springer.com/article/10.1186/s13041-019-0482-z

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