Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus

Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus

Lupus pathogenesis is associated with high type 1 interferon stimulated gene (ISG) expression. Here, the authors correlate ISG expression in CD8+ T cells from lupus nephritis patients with abnormal mitochondrial function, implicating increased NAD consumption and reduced cell viability in the pathog...

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Bibliographic Details
Main Authors: Norzawani Buang, Lunnathaya Tapeng, Victor Gray, Alessandro Sardini, Chad Whilding, Liz Lightstone, Thomas D. Cairns, Matthew C. Pickering, Jacques Behmoaras, Guang Sheng Ling, Marina Botto
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22312-y

Internet

https://doi.org/10.1038/s41467-021-22312-y

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