Plumbagin attenuates traumatic tracheal stenosis in rats and inhibits lung fibroblast proliferation and differentiation via TGF-β1/Smad and Akt/mTOR pathways

Plumbagin attenuates traumatic tracheal stenosis in rats and inhibits lung fibroblast proliferation and differentiation via TGF-β1/Smad and Akt/mTOR pathways

Traumatic tracheal stenosis (TS) is a serious respiratory disease characterized by hyperplasia of airway granulation. Plumbagin (PLB) is a natural naphthoquinone component with anti-fibrotic properties. This research aimed to explore the roles of PLB in alleviating TS and the underlying mechanisms....

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Bibliographic Details
Main Authors: Wei Shi, Yuanyuan Fang, Yueming Jiang, Siyang Jiang, Yu Li, Wentao Li, Mingpeng Xu, Michael Aschner, Guangnan Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Bioengineered
Subjects:
tracheal stenosis
plumbagin
tgf-β1
akt
samd2/3
mtor
fibroblast
proliferation
differentiation
Online Access:http://dx.doi.org/10.1080/21655979.2021.1954580

Internet

http://dx.doi.org/10.1080/21655979.2021.1954580

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