Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices

Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices

Efficacy of cytotoxic T lymphocyte (CTL)-based immunotherapy is still unsatisfactory against solid tumors, which are frequently characterized by condensed extracellular matrix. Here, using a unique 3D killing assay, we identify that the killing efficiency of primary human CTLs is substantially impai...

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Bibliographic Details
Main Authors: Renping Zhao, Xiangda Zhou, Essak S. Khan, Dalia Alansary, Kim S. Friedmann, Wenjuan Yang, Eva C. Schwarz, Aránzazu del Campo, Markus Hoth, Bin Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
CTLs
collagen
dense matrices
microtubules
migration
nuclear deformation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.729820/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.729820/full

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