Canonical transient receptor potential 6 channel deficiency promotes smooth muscle cells dedifferentiation and increased proliferation after arterial injury

Canonical transient receptor potential 6 channel deficiency promotes smooth muscle cells dedifferentiation and increased proliferation after arterial injury

Objective: Previous studies showed the benefit of canonical transient receptor potential 6 (TRPC6) channel deficiency in promoting endothelial healing of arterial injuries in hypercholesterolemic animals. Long-term studies utilizing a carotid wire-injury model were undertaken in wild-type (WT) and T...

Full description

Bibliographic Details
Main Authors: Andrew H. Smith, MD, Priya Putta, PhD, Erin C. Driscoll, BS, Pinaki Chaudhuri, PhD, Lutz Birnbaumer, PhD, Michael A. Rosenbaum, MD, Linda M. Graham, MD
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:JVS - Vascular Science
Subjects:
Smooth muscle cells
TRPC6
Phenotypic modulation
Intimal hyperplasia
Carotid injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2666350320300134

Internet

http://www.sciencedirect.com/science/article/pii/S2666350320300134

Similar Items