Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase

Engineering and Characterization of Oncolytic Vaccinia Virus Expressing Truncated Herpes Simplex Virus Thymidine Kinase

Oncolytic viruses are a promising class of anti-tumor agents; however, concerns regarding uncontrolled viral replication have led to the development of a replication-controllable oncolytic vaccinia virus (OVV). The engineering involves replacing the native <i>thymidine kinase</i> (<i&...

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Bibliographic Details
Main Authors: S. M. Bakhtiar Ul Islam, Bora Lee, Fen Jiang, Eung-Kyun Kim, Soon Cheol Ahn, Tae-Ho Hwang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
oncolytic viruses
vaccinia virus
herpes simplex virus type 1
thymidine kinase
ganciclovir
Online Access:https://www.mdpi.com/2072-6694/12/1/228

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https://www.mdpi.com/2072-6694/12/1/228

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