Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment?

Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment?

Biological and histopathological techniques identified osteoclasts and macrophages as targets of zoledronic acid (ZA), a therapeutic agent that was detrimental for patients in the French OS2006 trial. Conventional and multiplex immunohistochemistry of microenvironmental and OS cells were performed o...

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Bibliographic Details
Main Authors: Anne Gomez-Brouchet, Julia Gilhodes, Nathalie Van Acker, Regis Brion, Corinne Bouvier, Pauline Assemat, Nathalie Gaspar, Sebastien Aubert, Jean-Marc Guinebretiere, Beatrice Marie, Frederique Larousserie, Natacha Entz-Werlé, Gonzague de Pinieux, Eric Mascard, Francois Gouin, Pierre Brousset, Marie-Dominique Tabone, Marta Jimenez, Marie-Cecile Le Deley, Jean-Yves Blay, Laurence Brugieres, Sophie Piperno-Neumann, Francoise Rédini
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
osteosarcoma
zoledronic acid
osteoclast
macrophage
bipotent macrophage
multiplex
Online Access:https://www.mdpi.com/2072-6694/13/3/423

Internet

https://www.mdpi.com/2072-6694/13/3/423

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