RPA Stabilization of Single-Stranded DNA Is Critical for Break-Induced Replication

RPA Stabilization of Single-Stranded DNA Is Critical for Break-Induced Replication

DNA double-strand breaks (DSBs) are cytotoxic lesions that must be accurately repaired to maintain genome stability. Replication protein A (RPA) plays an important role in homology-dependent repair of DSBs by protecting the single-stranded DNA (ssDNA) intermediates formed by end resection and by fac...

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Bibliographic Details
Main Authors: Patrick Ruff, Roberto A. Donnianni, Eleanor Glancy, Julyun Oh, Lorraine S. Symington
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Cell Reports
Subjects:
homologous recombination
DSB repair
break-induced replication
RPA
Rad51
Dna2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716316746

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http://www.sciencedirect.com/science/article/pii/S2211124716316746

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