Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cells.

Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cells.

Nurr1 is an orphan nuclear receptor best known for its essential role in the development and maintenance of midbrain dopaminergic (DA) neurons. During DA neurogenesis, Nurr1 directly targets human tyrosine hydroxylase (hTH). Here we investigated this targeting to identify the molecular mechanisms by...

Full description

Bibliographic Details
Main Authors: Tae Eun Kim, Ji-Seon Seo, Jae Won Yang, Min Woong Kim, Rukhsana Kausar, Eunhye Joe, Bo Yeon Kim, Myung Ae Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3743743?pdf=render

Internet

http://europepmc.org/articles/PMC3743743?pdf=render

Similar Items